a new antibody for internal bleeding

New antibody to save severely-injured patients
Tue, 27 Oct 2009 13:37:21 GMT

An antibody that can minimize the major internal bleeding
frequently reported following traumas has been recently
discovered, a new study says.

According to the study published in Nature Medicine, a
protein known as histone is responsible for the major
internal bleeding seen after traumas such as battlefield
injuries, bullet wounds and car crashes.

The newly-discovered monoclonal antibody can block the
action of histones and therefore be used to treat diseases
and serious injuries.

"When a patient is suffering from severe bleeds, these
antibodies could prevent multi-organ failure," said lead
researcher Charles Esmon.

Under normal circumstances, the histone protein is normally
located in the nucleus, aiming to keep DNA tightly coiled
and packed and subsequently form the characteristic double
helix.

When the cell is damaged through injury, infection or
disease, the histone is released into the blood system,
leading to uncontrolled bleeding by killing the lining of
blood vessels.

The Oklahoma Medical Research Foundation (OMRF) team is
optimistic that its findings will help develop new
treatments to save those suffering from life threatening
injuries, severe infectious diseases and diabetes.

PKH/HGH
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http://www.presstv.ir/detail.aspx?id9749&sectionid510210
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