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Gut Bacteria Play Key Role in Immune System

Von: pautrey (rpautrey2@gmail.com) [Profil]
Datum: 04.06.2010 21:58
Message-ID: <aec93116-76bf-4457-9fed-ab92c7dd3963@m33g2000vbi.googlegroups.com>
Newsgroup: misc.health.alternative misc.kids.health alt.health
Gut Bacteria Play Key Role in Immune System

By Michael Smith, North American Correspondent, MedPage Today
October 16, 2008

NEW YORK, Oct. 16 -- The development of key immune cells is triggered
by specific types of bacteria in the gut, a finding that could lead to
new therapies for diseases of inflammation, researchers here said.

In the absence of bacteria from the cytophaga-flavobacter-
bacteroidetes phylum -- or CFB, for short -- the immune cells are also
not present, at least in mice, according to Dan Littman, M.D., Ph.D.,
of New York University, and colleagues.

On the other hand, when bacteria from that phylum are introduced into
animals lacking them, the result is a restoration of Th17 immune
cells, Dr. Littman and colleagues said in the Oct. 16 issue of Cell
Host & Microbe.

Th17 cells -- CD4-positive cells that have a potent pro-inflammatory
effect-- are normally in a balance with another population of CD4-
positive cells, dubbed Foxp3-positive cells, which play a regulatory
role in the immune system.

The finding that different populations of gut bacteria influence the
development of the Th17 cells could open the door to new treatments
for inflammatory bowel disease and other illnesses of the immune
system, Dr. Littman said.

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