Vitamin D deficiency, endotoxemia and obesity

The association runs through cathelicidin and the EGFR.

Curr Pharm Des. 2009;15(23):2751-8.

Vitamin D deficiency: the invisible accomplice of metabolic endotoxemia?
Lee P, Campbell LV.
Department of Endocrinology, Garvan Institute of Medical Research,
Sydney, New South Wales, Australia.

The aetiology of obesity is multi-factorial. Recent research has
identified a novel association between endotoxaemia (circulating
lipopolysaccharide in the systemic circulation) and low-grade
inflammation in the adipose organ, which may contribute to obesity. The
mechanisms for the low-grade elevation of circulating lipopolysaccharide
in obesity are poorly understood. Vitamin D has been increasingly
recognised for its pleiotropic actions beyond maintenance of
musculoskeletal health. The parathyroid-vitamin D axis is altered in
obesity. Circulating vitamin D levels are lower in obese individuals.
The regulatory role of vitamin D in the immune system and colonic mucosa
may explain the under-appreciated contribution of vitamin D deficiency
in the obese to the pathogenesis of endotoxaemia and adipose
inflammation. We propose a hypothetical model linking metabolic
endotoxaemia with vitamin D deficiency in obesity. A therapeutic
approach involving the use of probiotics and vitamin D metabolites in
the obese is described.
PMID: 19689344
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Nomen (30.10.2009 01:32)
Ernie (30.10.2009 18:52)