Vitamin Supplements maybe useful to preserve esophageal health

http://www.pubmedcentral.nih.gov/picrender.fcgi?artid#66201&blobtype=pdf

Nutr Cancer. 2008 Jan-Feb;60(1):39-48.

Dietary supplement use and risk of neoplastic
progression in esophageal adenocarcinoma:
a prospective study.

Dong LM, Kristal AR, Peters U, Schenk JM, Sanchez CA,
Rabinovitch PS, Blount PL, Odze RD, Ayub K, Reid BJ,
Vaughan TL.

Cancer Prevention Program,
Fred Hutchinson Cancer Research Center,
and Department of Epidemiology,
University of Washington,
Seattle, WA 98109, USA.

The incidence of esophageal adenocarcinoma (EA) and its precursor
condition,
Barrett's esophagus, has risen rapidly in the United States for
reasons that are
not fully understood. Therefore, we evaluated the association between
use of
supplemental vitamins and minerals and risk of neoplastic progression
of
Barrett's esophagus and EA. The Seattle Barrett's Esophagus Program is
a
prospective study based on 339 men and women with histologically
confirmed
Barrett's esophagus. Participants underwent baseline and periodic
follow-up
exams, which included endoscopy and self-administered questionnaires
on diet,
supplement use, and lifestyle characteristics. Use of multivitamins
and 4
individual supplements was calculated using time-weighted averages of
reported
use over the observational period. Cox proportional-hazards models
were used to
calculate hazard ratios (HR) for each endpoint: EA, tetraploidy, and
aneuploidy.
During a mean follow-up of 5 yr, there were 37 cases of EA, 42 cases
of
tetraploidy, and 34 cases of aneuploidy. After controlling for
multiple
covariates including diet, nonsteroidal anti-inflammatory drug use,
obesity, and
smoking, participants who took 1 or more multivitamin pills/day had a
significantly decreased risk of tetraploidy [HR = 0.19; 95% confidence
interval
(CI) = 0.08-0.47) and EA (HR = 0.38; 95% CI = 0.15-0.99] compared to
those not
taking multivitamins. Significant inverse associations were also
observed between
risk of EA and supplemental vitamin C (> or = 250 mg vs. none: HR
0.25; 95% CI
= 0.11-0.58) and vitamin E (> or = 180 mg vs. none: HR = 0.25; 95% CI

0.10-0.60).

In this cohort study, use of multivitamins and single
antioxidant supplements was associated with a significantly
reduced risk of EA and markers of neoplastic progression
among individuals with Barrett's esophagus.

PMCID: PMC2366201
PMID: 18444134

Never trust the newspaper.................Trig
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